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Issue 24, 2012
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PTSA-catalyzed Mannich-type–cyclization–oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes

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Abstract

A convenient one-pot Mannich-type–cyclization–oxidation tandem process has been developed for the synthesis of 1,3,5-trisubstituted pyrazoles derivatives from aldehydes, hydrazines and alkynes using p-toluenesulfonic acid monohydrate (PTSA) as a multifunctional catalyst. This method provides a flexible and rapid route to 1,3,5-trisubstituted pyrazoles.

Graphical abstract: PTSA-catalyzed Mannich-type–cyclization–oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes

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Publication details

The article was received on 06 Mar 2012, accepted on 06 May 2012 and first published on 08 May 2012


Article type: Communication
DOI: 10.1039/C2OB25487E
Citation: Org. Biomol. Chem., 2012,10, 4696-4698
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    PTSA-catalyzed Mannich-type–cyclization–oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes

    P. Liu, Y. Pan, Y. Xu and H. Wang, Org. Biomol. Chem., 2012, 10, 4696
    DOI: 10.1039/C2OB25487E

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