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Issue 25, 2012
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Catalyst development for organocatalytic hydrosilylation of aromatic ketones and ketimines

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Abstract

A new family of Lewis basic 2-pyridyl oxazolines have been developed, which can act as efficient organocatalysts for the enantioselective reduction of prochiral aromatic ketones and ketimines with trichlorosilane, a readily available and inexpensive reagent. 1-Isoquinolyl oxazoline, derived from mandelic acid, was identified as the most efficient catalyst of the series, capable of delivering high enantioselectivities in the reduction of both ketones (up to 94% ee) and ketimines (up to 89% ee).

Graphical abstract: Catalyst development for organocatalytic hydrosilylation of aromatic ketones and ketimines

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Publication details

The article was received on 04 Mar 2012, accepted on 24 Apr 2012 and first published on 25 Apr 2012


Article type: Paper
DOI: 10.1039/C2OB25472G
Citation: Org. Biomol. Chem., 2012,10, 4864-4877
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    Catalyst development for organocatalytic hydrosilylation of aromatic ketones and ketimines

    A. V. Malkov, A. J. P. Stewart-Liddon, G. D. McGeoch, P. Ramírez-López and P. Kočovský, Org. Biomol. Chem., 2012, 10, 4864
    DOI: 10.1039/C2OB25472G

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