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Issue 23, 2012
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Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct

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Abstract

A photolabile o-nitrobenzyl linker–cyclooctyne conjugate was prepared, immobilized on poly(methacrylate) beads and utilized as a trap for azide-functionalized compounds. These could be released by 365 nm UV light irradiation in high yield and purity. The “reagent-free” and time economic catch and release protocol was deemed useful for chemical proteomics applications.

Graphical abstract: Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct

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Publication details

The article was received on 29 Feb 2012, accepted on 26 Apr 2012 and first published on 26 Apr 2012


Article type: Communication
DOI: 10.1039/C2OB25440A
Citation: Org. Biomol. Chem., 2012,10, 4496-4499
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    Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct

    M. Golkowski, C. Pergola, O. Werz and T. Ziegler, Org. Biomol. Chem., 2012, 10, 4496
    DOI: 10.1039/C2OB25440A

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