Issue 31, 2012

Unsymmetrical tetrasubstituted ureas from tertiary carbamoylimidazole: activation by AlMe3

Abstract

An efficient and general method for the synthesis of unsymmetrical tetrasubstituted ureas from carbamoylimidazole is described. The conversion is achieved by the concurrent quarternization of the imidazole nitrogen and activation of amines with AlMe3.

Graphical abstract: Unsymmetrical tetrasubstituted ureas from tertiary carbamoylimidazole: activation by AlMe3

Supplementary files

Article information

Article type
Paper
Submitted
25 Feb 2012
Accepted
01 Jun 2012
First published
13 Jun 2012

Org. Biomol. Chem., 2012,10, 6420-6431

Unsymmetrical tetrasubstituted ureas from tertiary carbamoylimidazole: activation by AlMe3

A. Velavan, S. Sumathi and K. K. Balasubramanian, Org. Biomol. Chem., 2012, 10, 6420 DOI: 10.1039/C2OB25412C

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