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Issue 30, 2012
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Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

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Abstract

Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal–Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to residence time and temperature.

Graphical abstract: Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

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Publication details

The article was received on 24 Feb 2012, accepted on 21 Mar 2012 and first published on 21 Mar 2012


Article type: Communication
DOI: 10.1039/C2OB25407G
Citation: Org. Biomol. Chem., 2012,10, 5774-5779
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    Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

    P. B. Cranwell, M. O'Brien, D. L. Browne, P. Koos, A. Polyzos, M. Peña-López and S. V. Ley, Org. Biomol. Chem., 2012, 10, 5774
    DOI: 10.1039/C2OB25407G

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