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Issue 21, 2012
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A highly efficient one-pot reaction of 2-(gem-dibromovinyl)phenols(thiophenols) with K4Fe(CN)6 to 2-cyanobenzofurans(thiophenes)

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Abstract

2-Cyanobenzofurans and 2-cyanobenzothiophenes were prepared through an efficient one-pot Ullmann-reaction/cyanation reaction. In the presence of CuI/Na2CO3–Pd(OAc)2/PPh3 in DMF, the reaction of 2-(gem-dibromovinyl)phenols and 2-(gem-dibromovinyl)thiophenols with K4Fe(CN)6, as non-toxic and user-friendly cyanating reagent, proceeded smoothly to generate the corresponding 2-cyanobenzofurans and 2-cyanobenzothiophenes in good yields.

Graphical abstract: A highly efficient one-pot reaction of 2-(gem-dibromovinyl)phenols(thiophenols) with K4Fe(CN)6 to 2-cyanobenzofurans(thiophenes)

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Publication details

The article was received on 20 Feb 2012, accepted on 03 Apr 2012 and first published on 04 Apr 2012


Article type: Paper
DOI: 10.1039/C2OB25356A
Citation: Org. Biomol. Chem., 2012,10, 4172-4178
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    A highly efficient one-pot reaction of 2-(gem-dibromovinyl)phenols(thiophenols) with K4Fe(CN)6 to 2-cyanobenzofurans(thiophenes)

    W. Zhou, W. Chen and L. Wang, Org. Biomol. Chem., 2012, 10, 4172
    DOI: 10.1039/C2OB25356A

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