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Issue 30, 2012
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Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone

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Abstract

The intramolecular Staudinger-aza-Wittig reaction is used for a general synthesis of 1,2,5,6-tetrahydro-1,2,4-triazines, a structural motif reported for the natural product noelaquinone. The DEF moiety of noelaquinone was obtained in 13 steps and 2% overall yield, and the structure of the synthetic product was confirmed by X-ray analysis.

Graphical abstract: Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone

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Publication details

The article was received on 20 Feb 2012, accepted on 19 Mar 2012 and first published on 20 Mar 2012


Article type: Communication
DOI: 10.1039/C2OB25353D
Citation: Org. Biomol. Chem., 2012,10, 5811-5814
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    Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone

    L. Cao, J. P. Maciejewski, S. Elzner, D. Amantini and P. Wipf, Org. Biomol. Chem., 2012, 10, 5811
    DOI: 10.1039/C2OB25353D

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