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Issue 30, 2012
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Self condensation of enamines mediated by acetylation. A novel approach to 1-(azol-5-yl)-(1E,3Z)-butadiene-4-N,N-dimethylamines

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Abstract

Novel self-condensation of 3-(azol-5-yl)-1,1-dimethylenamines has been found to form new C–C bonds leading to 2,4-(1,2,3-triazole-1,2,3-thiadiazole-3-phenylisothiazole)-(1E,3Z)-5-yl-butadiene-1-amines. The discovered reaction represents a new example of C–H functionalization in unsaturated systems and can serve an efficient synthetic approach to rational design of new 2,4-(diazole-5-yl)-dieneamines.

Graphical abstract: Self condensation of enamines mediated by acetylation. A novel approach to 1-(azol-5-yl)-(1E,3Z)-butadiene-4-N,N-dimethylamines

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Publication details

The article was received on 15 Feb 2012, accepted on 29 Mar 2012 and first published on 29 Mar 2012


Article type: Communication
DOI: 10.1039/C2OB25331C
Citation: Org. Biomol. Chem., 2012,10, 5795-5798
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    Self condensation of enamines mediated by acetylation. A novel approach to 1-(azol-5-yl)-(1E,3Z)-butadiene-4-N,N-dimethylamines

    Y. Shafran, Y. Rozin, T. Beryozkina, S. Zhidovinov, O. Eltsov, J. Subbotina, J. Leban, R. Novikova and V. Bakulev, Org. Biomol. Chem., 2012, 10, 5795
    DOI: 10.1039/C2OB25331C

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