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Issue 19, 2012
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A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

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Abstract

A facile and highly enantioselective approach towards 2-substituted 3-bromopyrrolidines has been developed. The process involves an amino-thiocarbamate catalyzed bromoaminocyclization of 1,2-disubstituted olefinic amides. The pyrrolidine products could readily be converted into other useful building blocks including a dihydropyrrole and a 2-substituted pyrrolidine.

Graphical abstract: A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

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Publication details

The article was received on 14 Feb 2012, accepted on 06 Mar 2012 and first published on 07 Mar 2012


Article type: Communication
DOI: 10.1039/C2OB25327E
Citation: Org. Biomol. Chem., 2012,10, 3808-3811
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    A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

    J. Chen, L. Zhou and Y. Yeung, Org. Biomol. Chem., 2012, 10, 3808
    DOI: 10.1039/C2OB25327E

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