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Issue 30, 2012
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Amphiphilic α-helix mimetics based on a benzoylurea scaffold

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Abstract

The design and synthesis of amphiphilic benzoylurea α-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an α-helix.

Graphical abstract: Amphiphilic α-helix mimetics based on a benzoylurea scaffold

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Publication details

The article was received on 06 Feb 2012, accepted on 19 Mar 2012 and first published on 25 Apr 2012


Article type: Communication
DOI: 10.1039/C2OB25273B
Citation: Org. Biomol. Chem., 2012,10, 5780-5782
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    Amphiphilic α-helix mimetics based on a benzoylurea scaffold

    S. Thompson and A. D. Hamilton, Org. Biomol. Chem., 2012, 10, 5780
    DOI: 10.1039/C2OB25273B

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