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Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents

Zhangjian Huang,a   Junjie Fu,a   Ling Liu,a   Yijun Sun,b   Yisheng Lai,a   Hui Ji,a   Edward E. Knaus,c   Jide Tiand and   Yihua Zhang*a  
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Corresponding authors
a
Center of Drug Discovery, China Pharmaceutical University, Nanjing, P.R. China
E-mail: zyhtgd@163.com;
Fax: +86–25-83271015 ;
Tel: +86-25-83271015
b
Nanjing Keygen Biotech. Co., Nanjing, P.R. China
c
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
d
Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, USA
Org. Biomol. Chem., 2012,10, 3882-3891

DOI: 10.1039/C2OB25252J
Received 03 Feb 2012, Accepted 09 Mar 2012
First published online 09 Mar 2012
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