Jump to main content
Jump to site search

Issue 19, 2012
Previous Article Next Article

Enantioselective synthesis of bio-relevant 3,5-diaryl pyrazolines

Author affiliations

Abstract

The straightforward asymmetric construction of bio-relevant Δ2-pyrazolines having either N-(thio)amide or N-acetyl functional groups and flanked by aryl substituents such as phenol at C3 and C5 has been achieved through an enantioselective phase transfer organocatalytic addition of N-Boc hydrazine to chalcones followed by a transprotection sequence allowing N-Boc transformation into N-CXNHR (X = S, O) or N-Ac functional groups. This approach was applied to a straightforward elaboration of chiral monoamine oxidase inhibitor derivatives.

Graphical abstract: Enantioselective synthesis of bio-relevant 3,5-diaryl pyrazolines

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 31 Jan 2012, accepted on 15 Mar 2012 and first published on 11 Apr 2012


Article type: Paper
DOI: 10.1039/C2OB25227A
Citation: Org. Biomol. Chem., 2012,10, 3946-3954
  •   Request permissions

    Enantioselective synthesis of bio-relevant 3,5-diaryl pyrazolines

    O. Mahé, I. Dez, V. Levacher and J. Brière, Org. Biomol. Chem., 2012, 10, 3946
    DOI: 10.1039/C2OB25227A

Search articles by author