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Issue 30, 2012
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Synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block from D-glucose via fermentation

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Abstract

Herein we report the first synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block starting from glucose through pathway engineering of Escherichia coli and subsequent chemical modifications to provide an alternative method to produce KDO, found in plant and bacterial oligosaccharides.

Graphical abstract: Synthesis of a 3-deoxy-d-manno-octulosonic acid (KDO) building block from d-glucose via fermentation

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Publication details

The article was received on 20 Jan 2012, accepted on 08 Mar 2012 and first published on 16 Apr 2012


Article type: Paper
DOI: 10.1039/C2OB25168J
Citation: Org. Biomol. Chem., 2012,10, 5856-5860
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    Synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block from D-glucose via fermentation

    G. Camci-Unal, R. M. Mizanur, Y. Chai and N. L. B. Pohl, Org. Biomol. Chem., 2012, 10, 5856
    DOI: 10.1039/C2OB25168J

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