Issue 30, 2012

Synthesis of a 3-deoxy-d-manno-octulosonic acid (KDO) building block from d-glucosevia fermentation

Abstract

Herein we report the first synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block starting from glucose through pathway engineering of Escherichia coli and subsequent chemical modifications to provide an alternative method to produce KDO, found in plant and bacterial oligosaccharides.

Graphical abstract: Synthesis of a 3-deoxy-d-manno-octulosonic acid (KDO) building block from d-glucose via fermentation

Supplementary files

Article information

Article type
Paper
Submitted
20 Jan 2012
Accepted
08 Mar 2012
First published
16 Apr 2012

Org. Biomol. Chem., 2012,10, 5856-5860

Synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block from D-glucose via fermentation

G. Camci-Unal, R. M. Mizanur, Y. Chai and N. L. B. Pohl, Org. Biomol. Chem., 2012, 10, 5856 DOI: 10.1039/C2OB25168J

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