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Issue 16, 2012
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Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids

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Abstract

A practical, mild and highly selective protocol for the monodeuteration of a variety of arenes and heteroarenes is presented. Catalytic amounts of Ag(I) salts in DMSO/D2O are shown to facilitate the deutero-decarboxylation of ortho-substituted benzoic and heteroaromatic α-carboxylic acids in high yields with excellent levels of deuterium incorporation.

Graphical abstract: Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids

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Publication details

The article was received on 19 Jan 2012, accepted on 01 Mar 2012 and first published on 05 Mar 2012


Article type: Communication
DOI: 10.1039/C2OB25157D
Citation: Org. Biomol. Chem., 2012,10, 3172-3174
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    Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids

    R. Grainger, A. Nikmal, J. Cornella and I. Larrosa, Org. Biomol. Chem., 2012, 10, 3172
    DOI: 10.1039/C2OB25157D

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