Jump to main content
Jump to site search

Issue 17, 2012
Previous Article Next Article

Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

Author affiliations

Abstract

A 6-step procedure was developed for the synthesis of a new family of acyclic nucleoside phosphonates (ANPs), “PHEEPA” [(2-pyrimidinyl-2-(2-hydroxyethoxy)ethyl)phosphonic acids] in overall yields ranging from 4.5% to 32%. These compounds, which possess on one side a hydroxy function and on the other side a phosphonate group, can be considered either as potential antiviral agents or as transition state analogues of nucleoside phosphorylases such as thymidine phosphorylase.

Graphical abstract: Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 17 Jan 2012, accepted on 29 Feb 2012 and first published on 29 Feb 2012


Article type: Paper
DOI: 10.1039/C2OB25131K
Citation: Org. Biomol. Chem., 2012,10, 3448-3454
  •   Request permissions

    Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

    B. Dayde, S. Benzaria, C. Pierra, G. Gosselin, D. Surleraux, J. Volle, J. Pirat and D. Virieux, Org. Biomol. Chem., 2012, 10, 3448
    DOI: 10.1039/C2OB25131K

Search articles by author