Jump to main content
Jump to site search

Issue 30, 2012
Previous Article Next Article

Amphiphilic dynamic NDI and PDI probes: imaging microdomains in giant unilamellar vesicles

Author affiliations

Abstract

Dynamic amphiphiles provide access to transmembrane ion transport, differential sensing and cellular uptake. In this report, we introduce dynamic amphiphiles with fluorescent tails. Core-substituted naphthalenediimides (cNDIs) and perylenediimides (cPDIs) are tested. Whereas the latter suffer from poor partitioning, dynamic cNDI amphiphiles are found to be purifiable by RP-HPLC, to partition selectively into liquid-disordered (Ld) microdomains of mixed lipid bilayers and to activate DNA as transporters. Importantly, fluorescence properties, partitioning and activity can be modulated by changes in the structure of mixed amphiphiles. These results confirm the potential of dynamic fluorescent amphiphiles to selectively label extra- and intracellular membrane domains and visualize biological function.

Graphical abstract: Amphiphilic dynamic NDI and PDI probes: imaging microdomains in giant unilamellar vesicles

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 16 Jan 2012, accepted on 28 Feb 2012 and first published on 13 Apr 2012


Article type: Paper
DOI: 10.1039/C2OB25119A
Citation: Org. Biomol. Chem., 2012,10, 6087-6093
  •   Request permissions

    Amphiphilic dynamic NDI and PDI probes: imaging microdomains in giant unilamellar vesicles

    D. A. Doval, A. Fin, M. Takahashi-Umebayashi, H. Riezman, A. Roux, N. Sakai and S. Matile, Org. Biomol. Chem., 2012, 10, 6087
    DOI: 10.1039/C2OB25119A

Search articles by author