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Issue 30, 2012
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Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4)

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Abstract

The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade. In this perspective article, the design of CXCR4 agonists and antagonists from endogenous stromal cell-derived factor-1 (SDF-1)/CXCL12 and horseshoe crab-derived antimicrobial peptides and their therapeutic and diagnostic applications are described.

Graphical abstract: Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4)

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Publication details

The article was received on 14 Jan 2012, accepted on 16 Mar 2012 and first published on 19 Mar 2012


Article type: Perspective
DOI: 10.1039/C2OB25107H
Citation: Org. Biomol. Chem., 2012,10, 5720-5731
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    Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4)

    S. Oishi and N. Fujii, Org. Biomol. Chem., 2012, 10, 5720
    DOI: 10.1039/C2OB25107H

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