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Issue 23, 2012
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A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones

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Abstract

We present here a new, general, solid phase strategy for the synthesis of sequence independent peptidyl-fluoromethyl ketones using standard Fmoc peptide chemistry. Our method is based on the synthesis of bifunctional linkers which allows the incorporation of amino acid fluoromethyl ketone unit at the C-terminal end of peptide sequences. Application of this approach for the synthesis of activity based probes for SENPs is also described.

Graphical abstract: A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones

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Publication details

The article was received on 13 Jan 2012, accepted on 03 Apr 2012, published on 03 Apr 2012 and first published online on 03 Apr 2012


Article type: Paper
DOI: 10.1039/C2OB25096A
Citation: Org. Biomol. Chem., 2012,10, 4516-4523
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    A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones

    G. Roiban, M. Matache, N. D. Hădade and D. P. Funeriu, Org. Biomol. Chem., 2012, 10, 4516
    DOI: 10.1039/C2OB25096A

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