Jump to main content
Jump to site search

Issue 30, 2012
Previous Article Next Article

Construction of multi-component supramolecular architectures of bile acids and cinchona alkaloids through helical-pitch-synchronized crystallization

Author affiliations

Abstract

Molecular assemblies based on helical motifs are of substantial interest from the view point of fundamental science as well as application. In this study, we propose a new class of organic crystal, that is, heteroH-MOC (multi-component organic crystal containing different kinds of helical motifs consisted of different components), and describe successful construction of heteroH-MOCs with P21 and P212121 space groups by using steroidal bile acids and cinchona alkaloids. In the P21 crystals, two kinds of helices composed of the steroid and alkaloid are arranged in a parallel fashion, while, in the P212121 crystals, those are in a perpendicular fashion. It is remarkable that, in such systems, particularly in the latter crystals, components ingeniously achieved highly-ordered synchronization of periodicity (helical pitches r and periodic distances in the array of helices p), which is first demonstrated in this study through hierarchical interpretation of the crystal structures.

Graphical abstract: Construction of multi-component supramolecular architectures of bile acids and cinchona alkaloids through helical-pitch-synchronized crystallization

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 11 Jan 2012, accepted on 15 Mar 2012 and first published on 15 Mar 2012


Article type: Paper
DOI: 10.1039/C2OB25072A
Citation: Org. Biomol. Chem., 2012,10, 5985-5992
  •   Request permissions

    Construction of multi-component supramolecular architectures of bile acids and cinchona alkaloids through helical-pitch-synchronized crystallization

    T. Sasaki, N. Shizuki, E. Hiraishi, I. Hisaki, N. Tohnai and M. Miyata, Org. Biomol. Chem., 2012, 10, 5985
    DOI: 10.1039/C2OB25072A

Search articles by author