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Issue 30, 2012
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Combined coinage metal catalysis in natural product synthesis: total synthesis of (+)-varitriol and seven analogs

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Abstract

A modular total synthesis of the natural product (+)-varitriol (1) and seven analogs was achieved by using combined coinage metal catalysis. Starting from enynol 13, reagent-controlled introduction of stereogenic centers and efficient center-to-axis-to-center chirality transfer via α-hydroxyallene 5 afforded (+)-varitriol with 6.4% yield over 10 steps.

Graphical abstract: Combined coinage metal catalysis in natural product synthesis: total synthesis of (+)-varitriol and seven analogs

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Publication details

The article was received on 10 Jan 2012, accepted on 20 Feb 2012 and first published on 13 Mar 2012


Article type: Paper
DOI: 10.1039/C2OB25069A
Citation: Org. Biomol. Chem., 2012,10, 5965-5970
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    Combined coinage metal catalysis in natural product synthesis: total synthesis of (+)-varitriol and seven analogs

    T. Sun, C. Deutsch and N. Krause, Org. Biomol. Chem., 2012, 10, 5965
    DOI: 10.1039/C2OB25069A

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