without changing your settings we'll assume you are happy to receive all RSC cookies.
You can change your cookie settings by navigating to our Privacy and Cookies page and following the instructions. These instructions
are also obtainable from the privacy link at the bottom of any RSC page.
Developing novel methods for metal-induced switching of peptide structures expands the design principles of functional biomolecules and biomaterials. Here, a simple method for on-resin synthesis of dipicolylamine (Dpa)-containing peptides was developed. Whereas addition of divalent metal ions such as Fe(II) and Cu(II) to a peptide bearing a pair of Dpa moieties at the i and i + 4 positions led to the formation of a 1:1 complex of Dpa with metals, addition of Ni(II) yielded a cross-linked structure of Dpa–metal (2:1). This feature was utilized for the selective detection of Ni(II) using the peptide–Fe(II) complex. Repeated switching of the helical structure was also achieved by multiple additions of divalent metal ions to the peptide.
Fetching data from CrossRef. This may take some time to load.
Organic & Biomolecular Chemistry
- Information Point