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Issue 25, 2012
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Traceless chemical ligations from O-acyl serine sites

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Abstract

Chemical ligation via O- to N-acyl transfer of O-acylated serine containing peptides affords serine containing native peptides via 8- and 11-membered cyclic transition states opening the door to a wide variety of potential applications to peptide elaboration. The feasibility of these traceless chemical ligations is feasible as supported by computation.

Graphical abstract: Traceless chemical ligations from O-acyl serine sites

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Publication details

The article was received on 07 Dec 2011, accepted on 11 Apr 2012 and first published on 16 Apr 2012


Article type: Communication
DOI: 10.1039/C2OB07050B
Citation: Org. Biomol. Chem., 2012,10, 4836-4838
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    Traceless chemical ligations from O-acyl serine sites

    M. El Khatib, M. Elagawany, F. Jabeen, E. Todadze, O. Bol'shakov, A. Oliferenko, L. Khelashvili, S. A. El-Feky, A. Asiri and A. R. Katritzky, Org. Biomol. Chem., 2012, 10, 4836
    DOI: 10.1039/C2OB07050B

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