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Issue 21, 2012
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Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines

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Abstract

A facile solid phase synthesis of 2,4,6,7-tetrasubstituted pyrrolo[2,3-d]pyrimidines is described. The synthesis involves a highly efficient five-step route starting from resin-bound dimeric peptoids. To demonstrate the versatility of our method, a representative library of 108 tetrasubstituted pyrrolo[2,3-d]pyrimidines of high quality was synthesized.

Graphical abstract: Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines

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Publication details

The article was received on 10 Nov 2011, accepted on 02 Apr 2012 and first published on 03 Apr 2012


Article type: Paper
DOI: 10.1039/C2OB06899K
Citation: Org. Biomol. Chem., 2012,10, 4229-4235
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    Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines

    J. H. Lee and H. Lim, Org. Biomol. Chem., 2012, 10, 4229
    DOI: 10.1039/C2OB06899K

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