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Issue 5, 2012
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Stereoselective synthesis of N-aryl proline amides by biotransformation–Ugi-Smiles sequence

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Abstract

An efficient combination of MAO-N-catalyzed desymmetrization of cyclic meso-amines with Ugi-Smiles multicomponent chemistry produced optically pure N-aryl proline amides. This method represents the first report of a fully asymmetric Ugi-Smiles process.

Graphical abstract: Stereoselective synthesis of N-aryl proline amides by biotransformation–Ugi-Smiles sequence

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Publication details

The article was received on 07 Oct 2011, accepted on 10 Nov 2011 and first published on 16 Nov 2011


Article type: Communication
DOI: 10.1039/C1OB06699D
Citation: Org. Biomol. Chem., 2012,10, 941-944
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    Stereoselective synthesis of N-aryl proline amides by biotransformation–Ugi-Smiles sequence

    A. Znabet, S. Blanken, E. Janssen, F. J. J. de Kanter, M. Helliwell, N. J. Turner, E. Ruijter and R. V. A. Orru, Org. Biomol. Chem., 2012, 10, 941
    DOI: 10.1039/C1OB06699D

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