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Issue 5, 2012
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Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent

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Abstract

The preparation of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using XtalFluor-E ([Et2NSF2]BF4) as cyclodehydration reagent is described. Various functionalized 1,3,4-oxadiazoles were synthesized and it was found that the use of acetic acid as an additive generally improved the yields.

Graphical abstract: Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent

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Publication details

The article was received on 02 Sep 2011, accepted on 27 Oct 2011 and first published on 07 Dec 2011


Article type: Paper
DOI: 10.1039/C1OB06512B
Citation: Org. Biomol. Chem., 2012,10, 988-993
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    Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent

    M. Pouliot, L. Angers, J. Hamel and J. Paquin, Org. Biomol. Chem., 2012, 10, 988
    DOI: 10.1039/C1OB06512B

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