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Issue 1, 2012
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Dynamic combinatorial libraries for the recognition of heavy metal ions

Jörg M. Klein,a  Vittorio Saggiomo,a  Lisa Reck,b  Ulrich Lüning*b  and  Jeremy K. M. Sanders*a 
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* Corresponding authors

a University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: jkms@cam.ac.uk
Fax: +44 (0)1223 336 17

b Otto-Diels-Institut für Organische Chemie, Olshausenstr. 40, Kiel, Germany
E-mail: luening@oc.uni-kiel.de
Fax: +49-431-880-1558
Tel: +49-431-880-2450

Abstract

We present the use of hydrazone dynamic combinatorial libraries (DCLs) to identify macrocyclic receptors that are selective for alkaline earth metal ions over alkali metal ions. In particular, the toxic heavy metal ions Sr2+ and Ba2+ induce characteristic changes in the DCLs. Four macrocycles were isolated and characterised by LCMS, HRMS, NMR and X-ray crystallography; binding studies by UV-Vis spectroscopy confirm the selectivity observed in the DCLs.

Graphical abstract: Dynamic combinatorial libraries for the recognition of heavy metal ions

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Publication details

The article was received on 16 Jun 2011, accepted on 08 Sep 2011 and first published on 25 Oct 2011


Article type: Paper
DOI: 10.1039/C1OB05976A
Citation: Org. Biomol. Chem., 2012,10, 60-66
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    Dynamic combinatorial libraries for the recognition of heavy metal ions

    J. M. Klein, V. Saggiomo, L. Reck, U. Lüning and J. K. M. Sanders, Org. Biomol. Chem., 2012, 10, 60
    DOI: 10.1039/C1OB05976A

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