Issue 9, 2012
From the journal:

Organic & Biomolecular Chemistry

An efficient one pot transfer hydrogenation and N-alkylation of quinolines with alcohols mediated by Pd/C/Zn†

Belén Abarca,*a   Rosa Adama  and  Rafael Ballesteros*a  

* Corresponding authors

a Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, Avda. Vicente Andrés Estellés s/n, Burjassot (Valencia), Spain
E-mail: belen.abarca@uv.es, rafael.ballesteros@uv.es

Abstract

A Pd/C/Zn mixture with alcohols has been revealed to be an efficient transfer hydrogenation system to quinolines. Furthermore, the metals mixture is able to activate alcohols as N-alkylating agents in a hydrogen autotransfer process. 1,2,3,4-Tetrahydroquinolines and N-alkylated tetrahydroquinolines from quinolines have been obtained with excellent yields in one step.

Graphical abstract: An efficient one pot transfer hydrogenation and N-alkylation of quinolines with alcohols mediated by Pd/C/Zn

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Article information

DOI
https://doi.org/10.1039/C1OB05888F
Article type
Paper
Submitted
03 Jun 2011
Accepted
11 Oct 2011
First published
12 Oct 2011

Org. Biomol. Chem., 2012,10, 1826-1833

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An efficient one pot transfer hydrogenation and N-alkylation of quinolines with alcohols mediated by Pd/C/Zn

B. Abarca, R. Adam and R. Ballesteros, Org. Biomol. Chem., 2012, 10, 1826 DOI: 10.1039/C1OB05888F

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