Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 19, 2012
Previous Article Next Article

Folate-modified gold nanoclusters as near-infrared fluorescent probes for tumor imaging and therapy

Author affiliations

Abstract

Ultra-small gold nanoclusters (Au NCs) are highly promising materials for tumor imaging and therapy because of their low toxicity, intrinsic fluorescence, and the availability of multifunctional groups for covalent linkage of diverse bioactive molecules. Au NCs stabilized by bovine serum albumin (BSA) were prepared via an improved “green” synthetic routine. To ameliorate the selective affinity of Au NCs for high folate receptor (FR) expressing tumors, folic acid (FA) was immobilized on the surface of Au NCs. Subsequently, a near-infrared (NIR) fluorescent dye MPA was conjugated with Au–FA NCs for in vitro and in vivo fluorescence imaging. Similarly, Doxorubicin (DOX), a widely used clinical anticancer drug, was also conjugated to the folate-modified Au NCs to form a prodrug (Au–FA–DOX). Cellular and in vivo acute toxicity studies demonstrated the low toxicity of the Au–FA–MPA to normal cells and tissues. Additionally, in vitro and in vivo study of the dynamic behavior and targeting ability of Au–FA–MPA to different tumors validated the high selective affinity of Au–FA–MPA to FR positive tumors. With regard to the Au–FA–DOX, high anti-tumor activity was displayed by this pro-drug due to the FR mediated uptake. Herein, all of the results supported the potential of using ligand-modified Au NCs for tumor imaging and targeted therapy.

Graphical abstract: Folate-modified gold nanoclusters as near-infrared fluorescent probes for tumor imaging and therapy

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 25 Jun 2012, accepted on 07 Aug 2012 and first published on 15 Aug 2012


Article type: Paper
DOI: 10.1039/C2NR31616A
Citation: Nanoscale, 2012,4, 6050-6064
  •   Request permissions

    Folate-modified gold nanoclusters as near-infrared fluorescent probes for tumor imaging and therapy

    H. Chen, S. Li, B. Li, X. Ren, S. Li, D. M. Mahounga, S. Cui, Y. Gu and S. Achilefu, Nanoscale, 2012, 4, 6050
    DOI: 10.1039/C2NR31616A

Search articles by author