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Issue 17, 2012
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Cell “vision”: complementary factor of protein corona in nanotoxicology

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Abstract

Engineered nanoparticles are increasingly being considered for use as biosensors, imaging agents and drug delivery vehicles. Their versatility in design and applications make them an attractive proposition for new biological and biomedical approaches. Despite the remarkable speed of development in nanoscience, relatively little is known about the interaction of nanoscale objects with living systems. In a biological fluid, proteins associate with nanoparticles, and the amount and the presentation of the proteins on their surface could lead to a different in vivo response than an uncoated particle. Here, in addition to protein adsorption, we are going to introduce concept of cell “vision”, which would be recognized as another crucial factor that should be considered for the safe design of any type of nanoparticles that will be used in specific biomedical applications. The impact of exactly the same nanoparticles on various cells is significantly different and could not be assumed for other cells; the possible mechanisms that justify this cellular response relate to the numerous detoxification strategies that any particular cell can utilize in response to nanoparticles. The uptake and defence mechanism could be considerably different according to the cell type. Thus, what the cell “sees”, when it is faced with nanoparticles, is most likely dependent on the cell type.

Graphical abstract: Cell “vision”: complementary factor of protein corona in nanotoxicology

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Publication details

The article was received on 14 May 2012, accepted on 20 Jun 2012 and first published on 22 Jun 2012


Article type: Paper
DOI: 10.1039/C2NR31185B
Citation: Nanoscale, 2012,4, 5461-5468
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    Cell “vision”: complementary factor of protein corona in nanotoxicology

    M. Mahmoudi, S. N. Saeedi-Eslami, M. A. Shokrgozar, K. Azadmanesh, M. Hassanlou, H. R. Kalhor, C. Burtea, B. Rothen-Rutishauser, S. Laurent, S. Sheibani and H. Vali, Nanoscale, 2012, 4, 5461
    DOI: 10.1039/C2NR31185B

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