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Issue 17, 2012
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Short-peptide-based molecular hydrogels: novel gelation strategies and applications for tissue engineering and drug delivery

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Abstract

Molecular hydrogels hold big potential for tissue engineering and controlled drug delivery. Our lab focuses on short-peptide-based molecular hydrogels formed by biocompatible methods and their applications in tissue engineering (especially, 3D cell culture) and controlled drug delivery. This feature article firstly describes our recent progresses of the development of novel methods to form hydrogels, including the strategy of disulfide bond reduction and assistance with specific protein–peptide interactions. We then introduce the applications of our hydrogels in fields of controlled stem cell differentiation, cell culture, surface modifications of polyester materials by molecular self-assembly, and anti-degradation of recombinant complex proteins. A novel molecular hydrogel system of hydrophobic compounds that are only formed by hydrolysis processes was also included in this article. The hydrogels of hydrophobic compounds, especially those of hydrophobic therapeutic agents, may be developed into a carrier-free delivery system for long term delivery of therapeutic agents. With the efforts in this field, we believe that molecular hydrogels formed by short peptides and hydrophobic therapeutic agents can be practically applied for 3D cell culture and long term drug delivery in near future, respectively.

Graphical abstract: Short-peptide-based molecular hydrogels: novel gelation strategies and applications for tissue engineering and drug delivery

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Publication details

The article was received on 10 May 2012, accepted on 27 Jun 2012 and first published on 02 Jul 2012


Article type: Feature Article
DOI: 10.1039/C2NR31149F
Citation: Nanoscale, 2012,4, 5259-5267
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    Short-peptide-based molecular hydrogels: novel gelation strategies and applications for tissue engineering and drug delivery

    H. Wang and Z. Yang, Nanoscale, 2012, 4, 5259
    DOI: 10.1039/C2NR31149F

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