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Issue 13, 2012
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Biomimetic monolayer-protected gold nanoparticles for immunorecognition

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Abstract

Gold nanoparticles (AuNPs) protected by self-assembled monolayers (SAMs) are capable of presenting precisely engineered surfaces at the nanoscale, allowing the mimicry of biomacromolecules on an artificial platform. Here we review the generation, characterization, and applications of monolayer-protected AuNPs that have been designed for immunorecognition by the integration of an oligopeptide epitope into the protecting monolayer. The resulting peptide–AuNP conjugate is an effective platform for biomimesis, as demonstrated by multiple studies. Recent work is presented and future directions for this field of research are discussed.

Graphical abstract: Biomimetic monolayer-protected gold nanoparticles for immunorecognition

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Publication details

The article was received on 27 Feb 2012, accepted on 28 Apr 2012 and first published on 02 May 2012


Article type: Feature Article
DOI: 10.1039/C2NR30467H
Citation: Nanoscale, 2012,4, 3843-3851
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    Biomimetic monolayer-protected gold nanoparticles for immunorecognition

    K. M. Harkness, B. N. Turner, A. C. Agrawal, Y. Zhang, J. A. McLean and D. E. Cliffel, Nanoscale, 2012, 4, 3843
    DOI: 10.1039/C2NR30467H

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