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Issue 9, 2012
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Correlative light-ion microscopy for biological applications

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Abstract

Here we report a new technique, Correlative Light-Ion Microscopy (CLIM), to correlate SEM-like micrographs with fluorescence images. This technique presents significant advantages over conventional methods in enabling topographical and biochemical information to be correlated with nanoscale resolution without destroying the fluorescence signal. We demonstrate the utility of CLIM for a variety of investigations of cell substrate interactions validating its potential to become a routine procedure in biomedical research.

Graphical abstract: Correlative light-ion microscopy for biological applications

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Publication details

The article was received on 23 Feb 2012, accepted on 27 Feb 2012 and first published on 06 Mar 2012


Article type: Communication
DOI: 10.1039/C2NR30431G
Citation: Nanoscale, 2012,4, 2851-2854
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    Correlative light-ion microscopy for biological applications

    S. Bertazzo, T. von Erlach, S. Goldoni, P. L. Çandarlıoğlu and M. M. Stevens, Nanoscale, 2012, 4, 2851
    DOI: 10.1039/C2NR30431G

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