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Issue 7, 2012
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Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors

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Abstract

Iron oxide nanoparticles have found widespread applications in different areas including cell separation, drug delivery and as contrast agents. Due to water insolubility and stability issues, nanoparticles utilized for biological applications require coatings such as the commonly employed polyethylene glycol (PEG). Despite its frequent use, the influence of PEG coatings on the physicochemical and biological properties of iron nanoparticles has hitherto not been studied in detail. To address this, we studied the effect of 333–20 000 Da PEG coatings that resulted in larger hydrodynamic size, lower surface charge, longer circulation half-life, and lower uptake in macrophage cells when the particles were coated with high molecular weight (Mw) PEG molecules. By use of magnetic resonance imaging, we show coating-dependent in vivo uptake in murine tumors with an optimal coating Mw of 10 000 Da.

Graphical abstract: Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors

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Publication details

The article was received on 21 Oct 2011, accepted on 23 Jan 2012 and first published on 06 Mar 2012


Article type: Paper
DOI: 10.1039/C2NR11554A
Citation: Nanoscale, 2012,4, 2352-2361
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    Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors

    E. K. U. Larsen, T. Nielsen, T. Wittenborn, L. M. Rydtoft, A. R. Lokanathan, L. Hansen, L. Østergaard, P. Kingshott, K. A. Howard, F. Besenbacher, N. Chr. Nielsen and J. Kjems, Nanoscale, 2012, 4, 2352
    DOI: 10.1039/C2NR11554A

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