Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 15, 2012
Previous Article Next Article

Multi-photon imaging of amine-functionalized silica nanoparticles

Author affiliations


A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot™ CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e.g. with antibodies, proteins) in a single step for converting these photoluminescent SiO2 nanoparticles into multifunctional efficient vehicles for theragnostics.

Graphical abstract: Multi-photon imaging of amine-functionalized silica nanoparticles

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 19 Mar 2012, accepted on 17 Apr 2012 and first published on 03 May 2012

Article type: Paper
DOI: 10.1039/C2NR30660C
Citation: Nanoscale, 2012,4, 4680-4686
  •   Request permissions

    Multi-photon imaging of amine-functionalized silica nanoparticles

    F. Natalio, A. Kashyap, S. Lorenz, H. Kerschbaumer, M. Dietzsch, M. N. Tahir, H. Duschner, S. Strand, D. Strand and W. Tremel, Nanoscale, 2012, 4, 4680
    DOI: 10.1039/C2NR30660C

Search articles by author