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Issue 12, 2012
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Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice

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Abstract

Efficient transdermal insulin delivery to the systemic circulation would bring major benefit to diabetic patients. We investigated the possibility of using gold nanorods (GNRs) that formed a complex with an edible surfactant and insulin (INS) in an oil phase to form a solid-in-oil (SO) formulation (SO–INS–GNR) for transdermal treatment of diabetes. Diabetic mice comprised the model for our study. In vitro, there was high penetration of insulin through the stratum corneum (SC) and the dermis in mouse skin treated with an SO–INS–GNR complex plus near-infrared (NIR) light irradiation. Blood glucose levels in the diabetic mice were significantly decreased after treatment with SO–INS–GNR plus irradiation. To our knowledge, this is the first study to use gold nanorods for systemic insulin delivery through the skin. The use of an SO–INS–GNR complex combined with NIR irradiation may provide the possibility of transdermal insulin delivery to diabetic patients.

Graphical abstract: Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice

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Publication details

The article was received on 18 Mar 2012, accepted on 17 Apr 2012 and first published on 20 Apr 2012


Article type: Paper
DOI: 10.1039/C2NR30651D
Citation: Nanoscale, 2012,4, 3776-3780
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    Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice

    K. Nose, D. Pissuwan, M. Goto, Y. Katayama and T. Niidome, Nanoscale, 2012, 4, 3776
    DOI: 10.1039/C2NR30651D

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