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Issue 11, 2012
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Magnetic field enhanced cell uptake efficiency of magnetic silica mesoporous nanoparticles

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Abstract

The advantages of using magnetic mesoporous silica nanoparticles (M-MSNs) in biomedical applications have been widely recognized. However, poor uptake efficiency may hinder the potential of M-MSNs in many applications, such as cell tracking, drug delivery, fluorescence and magnetic resonance imaging. An external magnetic field may improve the cellular uptake efficiency. In this paper, we evaluated the effect of a magnetic field on the uptake of M-MSNs. We found that the internalization of M-MSNs by A549 cancer cells could be accelerated and enhanced by a magnetic field. An endocytosis study indicated that M-MSNs were internalized by A549 cells mainly through an energy-dependent pathway, namely clathrin-induced endocytosis. Transmission electron microscopy showed that M-MSNs were trafficked into lysosomes. With the help of a magnetic field, anticancer drug-loaded M-MSNs induced elevated cancer cell growth inhibition.

Graphical abstract: Magnetic field enhanced cell uptake efficiency of magnetic silica mesoporous nanoparticles

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Publication details

The article was received on 14 Feb 2012, accepted on 19 Mar 2012 and first published on 23 Mar 2012


Article type: Paper
DOI: 10.1039/C2NR30352C
Citation: Nanoscale, 2012,4, 3415-3421
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    Magnetic field enhanced cell uptake efficiency of magnetic silica mesoporous nanoparticles

    Q. Liu, J. Zhang, W. Xia and H. Gu, Nanoscale, 2012, 4, 3415
    DOI: 10.1039/C2NR30352C

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