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Issue 8, 2012
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Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent

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Abstract

Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin.

Graphical abstract: Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent

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Publication details

The article was received on 14 Oct 2011, accepted on 25 Nov 2011 and first published on 22 Dec 2011


Article type: Communication
DOI: 10.1039/C2NR11502F
Citation: Nanoscale, 2012,4, 2575-2579
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    Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent

    S. Dev, P. Prabhakaran, L. Filgueira, K. S. Iyer and C. L. Raston, Nanoscale, 2012, 4, 2575
    DOI: 10.1039/C2NR11502F

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