Real-time DNA detection using Pt nanoparticle-decorated reduced graphene oxide field-effect transistors

Zongyou Yin; Qiyuan He; Xiao Huang; Juan Zhang; Shixin Wu; Peng Chen; Gang Lu; Peng Chen; Qichun Zhang; Qingyu Yan; Hua Zhang

doi:10.1039/C1NR11149C

Real-time DNA detection using Pt nanoparticle-decorated reduced graphene oxide field-effect transistors

Zongyou Yin,†^a Qiyuan He,†^a Xiao Huang,^a Juan Zhang,^a Shixin Wu,^a Peng Chen,^ab Gang Lu,^a Peng Chen,^c Qichun Zhang,^a Qingyu Yan^a and Hua Zhang*^ab

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^a School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore
E-mail: hzhang@ntu.edu.sg, hzhang166@yahoo.com
Web: http://www.ntu.edu.sg/home/hzhang
Fax: +65 67909081

^b Center for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, Singapore

^c School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore

Abstract

A large-area, continuous, few-layer reduced graphene oxide (rGO) thin film has been fabricated on a Si/SiO₂ wafer using the Langmuir–Blodgett (LB) method followed by thermal reduction. After photochemical reduction of Pt nanoparticles (PtNPs) on rGO, the obtained PtNPs/rGO composite is employed as the conductive channel in a solution-gated field effect transistor (FET), which is then used for real-time detection of hybridization of single-stranded DNA (ssDNA) with high sensitivity (2.4 nM). Such a simple, but effective method for fabrication of rGO-based transistors shows great potential for mass-production of graphene-based electronic biosensors.

Nanoscale

Real-time DNA detection using Pt nanoparticle-decorated reduced graphene oxide field-effect transistors

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Real-time DNA detection using Pt nanoparticle-decorated reduced graphene oxide field-effect transistors

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