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Issue 10, 2012
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The structural role of the carrier protein – active controller or passive carrier

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Abstract

Covering: 2007 to 2011. Previous review: Nat. Prod. Rep., 2007, 24, 750

Common to all FASs, PKSs and NRPSs is a remarkable component, the acyl or peptidyl carrier protein (A/PCP). These take the form of small individual proteins in type II systems or discrete folded domains in the multi-domain type I systems and are characterized by a fold consisting of three major α-helices and between 60–100 amino acids. This protein is central to these biosynthetic systems and it must bind and transport a wide variety of functionalized ligands as well as mediate numerous protein–protein interactions, all of which contribute to efficient enzyme turnover. This review covers the structural and biochemical characterization of carrier proteins, as well as assessing their interactions with different ligands, and other synthase components. Finally, their role as an emerging tool in biotechnology is discussed.

Graphical abstract: The structural role of the carrier protein – active controller or passive carrier

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Publication details

The article was received on 24 May 2012, accepted on 31 Jul 2012 and first published on 24 Aug 2012


Article type: Review Article
DOI: 10.1039/C2NP20062G
Citation: Nat. Prod. Rep., 2012,29, 1111-1137
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    The structural role of the carrier protein – active controller or passive carrier

    J. Crosby and M. P. Crump, Nat. Prod. Rep., 2012, 29, 1111
    DOI: 10.1039/C2NP20062G

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