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Review Article

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

Zhao-Li Zhou,a   Ya-Xi Yang,b   Jian Ding,a   Yuan-Chao Li*b and   Ze-Hong Miao*a  
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a
Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai, P.R. China
E-mail: zhmiao@mail.shcnc.ac.cn;
Fax: +86-21-50806820 ;
Tel: + 86-21-50806820
b
Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai, P.R. China
E-mail: ycli@mail.shcnc.ac.cn;
Fax: + 86-21-50807288 ;
Tel: + 86-21-50807288
Nat. Prod. Rep., 2012,29, 457-475

DOI: 10.1039/C2NP00088A
Received 09 Nov 2011, First published online 23 Jan 2012
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