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Issue 8, 2012
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The generation of “unNatural” products: Synthetic biology meets synthetic chemistry

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Abstract

Covering: 2005 to 2012

Natural product analogue generation is important, providing tools for chemical biology, enabling structure activity relationship determination and insight into the way in which natural products interact with their target biomolecules. The generation of analogues is also often necessary in order to improve bioavailability and to fine tune compounds' activity. This review provides an overview of the catalogue of approaches available for accessing series of analogues. Over the last few years there have been major advances in genome sequencing and the development of tools for biosynthetic pathway engineering; it is therefore becoming increasingly easy to combine molecular biology and synthetic organic chemistry in order to enable expeditious access to series of natural products. This review outlines the various ways of combining biology and chemistry that have been applied to analogue generation, drawing upon a series of examples to illustrate each approach.

Graphical abstract: The generation of “unNatural” products: Synthetic biology meets synthetic chemistry

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Publication details

The article was received on 04 Jan 2012 and first published on 28 Jun 2012


Article type: Review Article
DOI: 10.1039/C2NP00001F
Citation: Nat. Prod. Rep., 2012,29, 870-889
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    The generation of “unNatural” products: Synthetic biology meets synthetic chemistry

    R. J. M. Goss, S. Shankar and A. A. Fayad, Nat. Prod. Rep., 2012, 29, 870
    DOI: 10.1039/C2NP00001F

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