Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 9, 2012
Previous Article Next Article

Lasso peptides: structure, function, biosynthesis, and engineering

Author affiliations


Covering: up to May 2012

Lasso peptides are a class of ribosomally-synthesized and posttranslationally-modified natural products with diverse bioactivities. This review describes the structure and function of all known lasso peptides (as of mid-2012) and covers our current knowledge about the biosynthesis of those molecules. The isolation and characterization of lasso peptides are also covered as are bioinformatics strategies for the discovery of new lasso peptides from genomic sequence data. Several studies on the engineering of new or improved function into lasso peptides are highlighted, and unanswered questions in the field are also described.

Graphical abstract: Lasso peptides: structure, function, biosynthesis, and engineering

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 16 Jun 2012 and first published on 25 Jul 2012

Article type: Review Article
DOI: 10.1039/C2NP20070H
Citation: Nat. Prod. Rep., 2012,29, 996-1006
  •   Request permissions

    Lasso peptides: structure, function, biosynthesis, and engineering

    M. O. Maksimov, S. J. Pan and A. James Link, Nat. Prod. Rep., 2012, 29, 996
    DOI: 10.1039/C2NP20070H

Search articles by author