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Issue 4, 2012
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Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

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Abstract

Covering: 1972 to 2011

Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure–activity relationships, pharmacology, and clinical development of triptolide in the last forty years.

Graphical abstract: Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

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Publication details

The article was received on 09 Nov 2011 and first published on 23 Jan 2012


Article type: Review Article
DOI: 10.1039/C2NP00088A
Citation: Nat. Prod. Rep., 2012,29, 457-475
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    Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

    Z. Zhou, Y. Yang, J. Ding, Y. Li and Z. Miao, Nat. Prod. Rep., 2012, 29, 457
    DOI: 10.1039/C2NP00088A

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