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Issue 7, 2012
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Multimodal and multifunctional stealth polymer nanospheres for sustained drug delivery

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Abstract

We report the preparation of fluorescent and magnetic PMMA nanospheres, and a corresponding PEGylated ‘stealth’ analogue prepared using a block copolymer. The nanospheres contain encapsulated magnetite nanoparticles and fluorescent BODIPY dyes, including a new such dye with pH-sensitive fluorescent emission. The new dye could potentially be used as an indicator of the immediate physiological environment. The nanospheres were non-toxic at up to 500 μg ml−1 in PC12 cells. Lomerizine, a lipophilic calcium channel blocker, was also encapsulated in the nanospheres and displayed sustained, pH-dependent release characteristics. The nanospheres may be of use to release lomerizine and other water-insoluble drugs at central nervous system injury sites.

Graphical abstract: Multimodal and multifunctional stealth polymer nanospheres for sustained drug delivery

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Publication details

The article was received on 09 Jan 2012, accepted on 24 Mar 2012 and first published on 02 Apr 2012


Article type: Paper
DOI: 10.1039/C2NJ40016B
Citation: New J. Chem., 2012,36, 1457-1462
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    Multimodal and multifunctional stealth polymer nanospheres for sustained drug delivery

    C. W. Evans, M. J. Latter, D. Ho, S. A. M. A. Peerzade, T. D. Clemons, M. Fitzgerald, S. A. Dunlop and K. S. Iyer, New J. Chem., 2012, 36, 1457
    DOI: 10.1039/C2NJ40016B

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