Issue 8, 2012

Controlled drug delivery from mesoporous silica using a pH-response release system

Abstract

Mesoporous hollow silica nanoparticles were functionalized with phenanthroline (P-MHS) to prepare a carrier for a host–guest complex. Curcumin was selected as a model drug molecule. The phenanthroline attached to the P-MHS was complexed with Cu2+ through a coordination bond. When the Cu2+P-MHS was exposed to ∼pH 5, the curcumin was efficiently released into the aqueous phase within 120 min. This work describes a method for functionalizing the surface of the porous silica nanoparticles in a well-defined manner. The P-MHS carrier exhibited controlled release of a model drug under acidic pH conditions.

Graphical abstract: Controlled drug delivery from mesoporous silica using a pH-response release system

Supplementary files

Article information

Article type
Paper
Submitted
21 Nov 2011
Accepted
14 May 2012
First published
22 Jun 2012

New J. Chem., 2012,36, 1616-1620

Controlled drug delivery from mesoporous silica using a pH-response release system

D. Jin, J. H. Lee, M. L. Seo, J. Jaworski and J. H. Jung, New J. Chem., 2012, 36, 1616 DOI: 10.1039/C2NJ20976D

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