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Department of Pediatrics and Department of Pharmacology, and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, USA
; Fax: 615-936-4080
; Tel: 615-322-8024
Metallomics, 2012,4, 593-605
19 Dec 2011,
03 Feb 2012
First published online
06 Feb 2012
Metals can have a number of detrimental or beneficial effects in the cell, but first they must get in. Organisms have evolved transport mechanisms to get metals that are required, or essential into the cell. Nonessential metals often enter the cell through use of the machinery provided for essential metals. Much work has been done to advance our understanding of how these metals are transported across plasma and organelle membranes. This review provides an overview of essential and nonessential metal transport and homeostatic processes.
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