The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?

Timothy J. Ritchie; Simon J. F. Macdonald; Simon Peace; Stephen D. Pickett; Christopher N. Luscombe

doi:10.1039/C2MD20111A

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The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?

Timothy J. Ritchie, Simon J. F. Macdonald, Simon Peace, Stephen D. Pickett and Christopher N. Luscombe

Med. Chem. Commun., 2012,3, 1062-1069

DOI: 10.1039/C2MD20111A
Received 02 May 2012, Accepted 12 Jun 2012
First published online 18 Jun 2012

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Aqueous solubility, protein binding and CYP450 inhibition data for compounds containing a variety of heteroaromatic and heteroaliphatic rings were analysed and compared to determine which ring types fared best and worst in these developability screens. The results suggest that certain heterorings are generally more developable than others: how this information may be used and some caveats to be borne in mind are discussed.

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Timothy J. Ritchie
Simon J. F. Macdonald
Simon Peace
Stephen D. Pickett
Christopher N. Luscombe

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The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?

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