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Issue 10, 2012
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Recent applications of multicomponent reactions in medicinal chemistry

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Abstract

Multicomponent reactions are flexible reactions for the rapid generation of complex molecules with often biologically relevant scaffold structures. Combined with the ease of parallelization and the exploratory power with regard to chemical space, multicomponent reactions have attracted significant attention from the medicinal chemistry community. In this Review, we present an overview of recent literature concerning this topic to provide insight into the applications of multicomponent reactions in this field.

Graphical abstract: Recent applications of multicomponent reactions in medicinal chemistry

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Publication details

The article was received on 09 Apr 2012, accepted on 14 Jun 2012 and first published on 25 Jul 2012


Article type: Review Article
DOI: 10.1039/C2MD20089A
Citation: Med. Chem. Commun., 2012,3, 1189-1218
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    Recent applications of multicomponent reactions in medicinal chemistry

    P. Slobbe, E. Ruijter and R. V. A. Orru, Med. Chem. Commun., 2012, 3, 1189
    DOI: 10.1039/C2MD20089A

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