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Issue 8, 2012
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Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis

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Abstract

Despite having served as a primary source for pharmaceutical agents, the physiological role played by natural products in their bacterial hosts is typically unknown. In addition, while terpenoids comprise the largest class of known natural products, it is unusual for these to be produced by bacteria. Accordingly, the recent findings demonstrating that Mycobacterium tuberculosis (Mtb) produces a diterpenoid, isotuberculosinol, is unusual in and of itself, and the accumulating evidence that this functions in the infection process of this pernicious human pathogen indicates a physiological role with medical relevance, all of which is reviewed here. Also presented is conservation of the biosynthetic capacity for isotuberculosinol production, which suggests that this is particularly important in Mtb, leading to speculation that this natural product may contribute to the highly infectious nature of Mtb in humans.

Graphical abstract: Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis

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Publication details

The article was received on 02 Feb 2012, accepted on 23 Mar 2012 and first published on 10 May 2012


Article type: Review Article
DOI: 10.1039/C2MD20030A
Citation: Med. Chem. Commun., 2012,3, 899-904
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    Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis

    F. M. Mann and R. J. Peters, Med. Chem. Commun., 2012, 3, 899
    DOI: 10.1039/C2MD20030A

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